7 Best Bed Bug Sprays for Mattress 2025

This heavy-hitting formula delivers a knockout punch to even the most stubborn infestations, making it a top-tier choice for homeowners facing recurring bed bug problems. With its EPA-registered, odorless spray, it offers up to 16 weeks of residual protection—a rare feat in the over-the-counter market—ensuring bugs don’t return after the initial kill. Its non-staining, scent-free design means you can treat mattresses, baseboards, and upholstery without fear of damage or lingering smells, directly addressing one of the biggest concerns for indoor pest control.

In real-world testing, the 32oz size proves highly efficient for whole-room treatments, especially along baseboards, behind furniture, and in mattress seams. The spray nozzle delivers a fine, even mist that penetrates deep into cracks and crevices where bed bugs hide, and the formula remains active long after drying—critical for interrupting the bed bug lifecycle. While it’s not intended for airborne bugs or large-scale fogging, it excels as a targeted, long-term barrier against reinfestation, particularly in apartments or rental units with shared walls.

Compared to fast-acting but short-lived options like Raid Foaming Spray, Harris stands out for sustained defense, trading immediate foaming visibility for months of silent protection. It’s the ideal pick for users who want a set-and-forget solution after an initial treatment, especially in high-risk environments like hotels or multi-family housing. While it lacks a comfort wand or travel-sized companion, its residual performance and professional-grade strength make it a smarter long-term investment than sprays that require weekly reapplication.

Ortho Home Defense Max brings systematic precision to bed bug control, pairing brute force with smart design to tackle infestations from multiple angles. The included Comfort Wand is a game-changer—its thin nozzle reaches deep into mattress tufts, bed frame joints, and baseboard gaps where sprays often fall short, ensuring no hiding spot is left untreated. Formulated to kill pyrethroid-resistant bed bugs and their eggs, this gallon-sized solution is built for users who need to treat large areas or recurring infestations across multiple rooms.

During application, the spray disperses evenly without dripping, and the spot-treatment approach minimizes overspray on fabrics and bedding. The formula dries quickly and leaves no stain or strong odor, making it safe for use around sleeping areas. However, it’s not designed for residual protection beyond a few weeks, so frequent reapplication is necessary for long-term prevention. It performs best when used as part of the full Ortho 3-Step System—without the companion detect-and-trap tools, coverage may be incomplete.

When stacked against Harris White Label, Ortho trades longevity for precision and volume, making it better suited for active, widespread infestations rather than passive prevention. It’s the go-to for users who want a full-room assault strategy with professional-style tools, especially those also battling fleas or ticks. While it doesn’t offer the 16-week residual of Harris, its comfort wand and system integration provide unmatched control in hard-to-reach zones.

Hygea Natural steps into the ring with a dual-purpose, travel-ready defense system that’s as effective on a hotel mattress as it is on your own bedroom set. This odorless, child- and pet-safe formula is built for peace of mind, allowing frequent spraying without chemical exposure risks—perfect for families or pet owners wary of harsh insecticides. The 24oz main spray delivers broad coverage, while the TSA-approved 3oz travel version makes it the only product in this lineup designed for proactive defense on the go, a lifesaver for frequent travelers.

In testing, the spray performs well on contact, killing visible bugs quickly, though it may require multiple applications to fully eradicate entrenched infestations due to its natural composition. It works on any water-friendly surface—mattresses, linens, suitcases, even clothing—without staining or residue, and the included step-by-step guide adds real value for first-time users. However, it lacks the long residual kill of chemical formulas, so it’s better suited for prevention and early-stage outbreaks than full-blown infestations.

Compared to EcoVenger, Hygea matches its natural safety profile but falls short in residual duration and independent lab validation. Still, its travel-ready design and dual-bottle setup make it the most versatile option for mobile lifestyles. For those who prioritize safety, portability, and ease of use, Hygea offers unmatched convenience—just don’t expect it to replace a heavy-duty chemical treatment in severe cases.

EcoVenger isn’t just another natural spray—it’s a scientifically validated, plant-powered assassin that outperforms many chemical rivals in independent studies. Backed by a published university trial, it ranks as the #1 natural bed bug killer among 12 tested, with 100% kill efficacy on contact and proven destruction of resistant strains and eggs. Its USDA BioBased certification and dermatologically safe formula make it ideal for homes with kids, pets, or allergy sufferers, offering toxic-free peace of mind without sacrificing power.

Real-world use confirms its potency: the spray works fast on direct application, and crucially, maintains a dry residual effect for up to two weeks—rare for botanical formulas. It’s safe to apply directly on mattresses, box springs, and upholstery without staining or odor, and its water-based delivery ensures even coverage without greasy residue. While it doesn’t last as long as Harris’s 16-week shield, it strikes the best balance between natural safety and lasting performance in the category.

Against Hygea, EcoVenger delivers superior residual kill and lab-backed credibility, making it the smarter pick for serious infestations where natural ingredients are non-negotiable. It’s the ultimate choice for eco-conscious users who refuse to compromise on effectiveness. While it lacks a travel size, its proven performance and extended protection make it the gold standard in natural bed bug control.

Raid Bed Bug Foaming Spray enters the arena with explosive speed and visible action, making it the go-to for users who want instant gratification and fast knockdown. The expanding foam is a standout—it creeps into seams, folds, and joints where sprays can’t reach, and its white color lets you see exactly where it’s applied, eliminating guesswork. Designed to kill pyrethroid-resistant bed bugs and eggs on contact, it delivers a powerful first strike within minutes of application.

In real use, the foam adheres well to vertical surfaces and dries quickly without staining, making it ideal for spot-treating mattress edges, zippers, and bed frames. It continues to kill for up to four weeks, offering moderate residual protection—solid for a budget option. However, it doesn’t penetrate as deeply as liquid sprays and may require multiple cans for full-room coverage, making it less cost-effective over time. It’s best used as a first-response weapon, not a long-term solution.

When compared to Harris or Ortho, Raid sacrifices system integration and long-term control for low cost and immediate results. It’s the smart pick for renters or students dealing with a sudden outbreak who need quick, visible action without commitment. While it doesn’t match the depth or duration of premium sprays, its foam visibility and fast kill make it the most satisfying budget-friendly emergency option.

Ecologic Bed Bug Killer wields a plant-powered punch in an aerosol shell, combining the convenience of a spray can with a natural, kid- and pet-safe formula. Infused with lemongrass and cornmint oils, this spray kills bed bugs and eggs on contact while emitting a mild, herbal scent—ideal for users avoiding synthetic chemicals. Its aerosol delivery ensures deep penetration into tight cracks and crevices, and the 14oz size fits easily in travel bags, making it a stealthy option for quick treatments at home or on the road.

In testing, the spray disperses evenly and dries fast without staining fabrics or leaving residue, allowing safe use on mattresses, luggage, and furniture. It’s particularly effective for spot treatments around bed frames, baseboards, and suitcase seams. However, as with most natural aerosols, it offers minimal residual protection, requiring reapplication every few days during active infestations. It also lacks the volume for whole-room coverage, so it’s best as a targeted, supplemental tool rather than a primary solution.

Next to Raid’s foam, Ecologic wins on safety and scent profile but loses on residual duration and knockdown speed. It’s the top pick for eco-focused users who want aerosol convenience without toxic fumes. While it won’t replace a heavy-duty liquid spray, its natural ingredients and portability make it a smart secondary defender in a broader pest control strategy.